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hematology diagnosis oncology management microscopy smear hemolytic leukemia workup agglutinin algorithm aplastic bodies body cancer cell chronic cll cold common
Sickle cell anemia and Howell Jolly bodies (nuclear remnants). - Dr. Abubaker Elshaikh @ElshaikhMD #SickleCell #HowellJolly #Body #Bodies
Sickle cell anemia ... #Body #Bodies #Pathology ... #Hematology #Smear ... #Clinical #Microscopy
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
microangiopathic hemolytic anemia ... DIC is a clinical ... non-specific red cell ... polychromatophilic cells ... #Hematology #Pathology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... transformation to AML ... • Aplastic Anemia ... progression to AML ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Release from blast cells ... • Induce blast cell ... Infection (sepsis), PE
A non-subtle example of true Sezary syndrome. Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... #Cells #Clinical ... #Pathology #Smear ... #Microscopy #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... Constitutional Syndromes ... marrow-failure syndromes ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Neutropenia, anemia ... • Richter’s Syndrome ... Transform to DLBCL, PML ... leukemia • Sezary syndrome
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... malignancies - B-cell ... sensitize red blood cells ... #hematology #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
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