9 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... Bone symptoms - Pain ... - Drugs - Primary ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... Labs: • Alkaline ... obstruction • ALP ... bile ducts Differential ... cholangitis #diagnosis #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... not required in all ... unclear, or if a primary ... #Workup #hematology
Chronic Abdominal Pain Causes - Differential Diagnosis Framework

Many patients with chronic abdominal pain have had prior
Causes - Differential ... Skin changes • Urinary ... dysfunction • PSC ... Ovarian CA Diffuse ... #Differential #
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... • ↑ PBS: Granulocytic ... + distinctive primary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... effusions, weight gain ... initiation • Differential ... fluid overload, PCC ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... Castleman disease • AL ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... Gap #ProteinGap #differential
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hemolytic anemia • Pain ... Hodgkin Lymphoma Workup ... platelets - WBC ... Immunohistochemical studies (to differentiate ... #oncology #management
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
presents with pain ... except for the primary ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology