10 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Liver Disease: Primary ... Biliary Cirrhosis ... vs Primary Sclerosing ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase ... - Drugs - Primary ... biliary Cholangitis ... - Other biliary ... Diagnosis #Algorithm #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... Pathophysiology ... #Primary #Biliary ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Pathophysiology ... Labs: • Alkaline ... #Biliary #Cirrhosis ... diagnosis #workup #hepatology
Algorithm for the Diagnosis of Primary Biliary Cholangitis (PBC). 

US, ultrasound; MRCP, magnetic resonance cholangiopancreatography; ALP,
the Diagnosis of Primary ... Biliary Cholangitis ... cholangiopancreatography; ALP, alkaline ... antibodies #Primary ... #Diagnosis #Hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Tests - AST, ALT, Alkaline ... CAST) • ALT: primarily ... Metabolism #ASTALT #AlkPhos ... #Bilirubin #Hepatology ... #Pathophysiology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Low Alkaline Phosphatase ... • Pernicious anemia ... collection with EDTA Pathophysiology ... • Elevation of urinary ... Hyophosphatasia #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... + Bleeding Treatment ... : • Treat primary ... diagnosis #causes #treatment ... #management #hematology
Primary Biliary Cirrhosis - Management
A. Initiate therapy 
 - Initiate 1st line therapy with UDCA (13-15
Primary Biliary ... survey disease #PBC ... #Primary #Biliary ... Cirrhosis #Management #Treatment ... #hepatology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
except for the primary ... • No CRAB - no anemia ... UPEP, Serum IFE, FLC ... Bone marrow Treatment ... Diagnosis #Workup #Hematology