22 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholangitis #pathophysiology ... #pbc #psc #hepatology
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology ... of Hemolytic Anemia ... environment #Pathophysiology ... #Hemolytic #Anemia ... #hematology
Aplastic Anemia Summary

 • Definition
 • Pathophysiology
 • DDx: AA vs Hypocellular MDS
 • Expectation
 •
Aplastic Anemia ... Definition • Pathophysiology ... #Aplastic #Anemia ... #diagnosis #oncology ... #hematololgy
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... relative with PBC ... Pathophysiology ... Cholestasis #PBC ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Biliary Cirrhosis (PBC ... ) - Summary PBC ... 30-65 years PBC ... Pathophysiology ... diagnosis #workup #hepatology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia ... #Classification ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... PLT • Reticulocyte ... #oncology #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... fluid overload, PCC ... diagnosis #management #hematology ... #oncology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Even with normal WBC ... 21% had normal WBC ... #CBC #hematology ... #pathophysiology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
for decreased PLT ... for decreased PLT ... changes), high MCV anemia ... disease), HBsAg/anti-HBc ... Causes #Workup #hematology