19 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Liver Disease: Primary ... Biliary Cirrhosis vs Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology ... of Hemolytic Anemia ... environment #Pathophysiology ... #Hemolytic #Anemia ... #hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase ... - Drugs - Primary ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC ... Diagnosis #Algorithm #hepatology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Reticulocytosis • Primary ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... Algorithm #Causes #Hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Cirrhosis (PBC) ... - Summary PBC ... Pathophysiology ... Labs: • Alkaline ... diagnosis #workup #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgM) (e.g. primary ... • Intrinsic RBC ... differential #diagnosis #hematology ... #anemia
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... relative with PBC ... Cholestasis #PBC ... #Primary #Biliary ... #hepatology
Algorithm for the Diagnosis of Primary Biliary Cholangitis (PBC). 

US, ultrasound; MRCP, magnetic resonance cholangiopancreatography; ALP,
the Diagnosis of Primary ... Biliary Cholangitis (PBC ... cholangiopancreatography; ALP, alkaline ... #Cholangitis #PBC ... Algorithm #Diagnosis #Hepatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
15% of AIHA Primary ... • Symptoms of anemia ... anemia • Cold ... Blood smear - RBC ... #anemia #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
for decreased PLT ... for decreased PLT ... changes), high MCV anemia ... unclear, or if a primary ... Causes #Workup #hematology