8 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... #Bridging #Dosing ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Betrixaban (Bevyxxa), Edoxaban ... Andexxa), 4-factor PCC ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
Anticoagulant Bridging

 • Switching from LMWH
 • Switching from UFH
 • Switching from DOAC to Warfarin
Anticoagulant Bridging ... Switching from DOAC ... from Warfarin to DOAC ... anticoagulation #pharmacology ... #management #hematology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... : • Apixaban, Edoxaban ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Diagnosis - If suspected ... , AIH diagnosis ... Hepatitis (eg Viral) Management ... Histology Findings (eg Bridging ... #Management #Hepatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
and Management ... heparin-PF4 complex → plt ... hypercoagulable state and plt ... , Bivalirudin, DOAC ... #Hematology #HemeOnc
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... • ↓ WBC • ↓ PLT ... #oncology #hematology ... #diagnosis #management
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
sometimes with thick ridging ... Diagnosis? ... • No CRAB - no anemia ... UPEP, Serum IFE, FLC ... #Workup #Hematology