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hematology anticoagulation anticoagulant vte algorithm cancer diagnosis malignancy noac oral reversal apixaban aplastic cell chemotherapy cyp3a4 dabigatran dosing dvt inducers
Oral anticoagulant dosing and bridging for VTE - Dr. Joseph Shatzel @Clotmaster #VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... #Bridging #Dosing ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Betrixaban (Bevyxxa), Edoxaban ... Andexxa), 4-factor PCC ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis. Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... anticoagulants (DOACs ... being stronger for edoxaban ... Anticoagulation #Management ... #Hematology #Oncology
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 (DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
Edoxaban, rivaroxaban ... pathway whereas edoxaban ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Anticoagulant Bridging • Switching from LMWH • Switching from UFH • Switching from DOAC to Warfarin
Anticoagulant Bridging ... Switching from DOAC ... from Warfarin to DOAC ... anticoagulation #pharmacology ... #management #hematology
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
DOAC Reversal Emergency ... : • Apixaban, Edoxaban ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
**Edoxaban is initiated ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management ... #Hematology #Oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... • ↓ WBC • ↓ PLT ... #oncology #hematology ... #diagnosis #management
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
sometimes with thick ridging ... • No CRAB - no anemia ... UPEP, Serum IFE, FLC ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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