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hematology anticoagulant chemotherapy cyp3a4 inducers interactions noac oncology oral perioperative pglycoprotein preop reversal table
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
) Cancer-treatment ... inducers (↑) and inhibitors ... Dabigatran has moderate ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Perioperative Management of DOACs Problem: ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Perioperative Management ... interruption per treatment ... of Therapy • Dabigatran ... direct thrombin inhibitor ... #Treatment #pharmacology
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... modified factor Xa • Dabigatran ... anticoagulant #hematology ... #management #pharmacology
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