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diagnosis hematology management apml biliary cholangitis differentiation dosing gap globulin indications monoclonal paraproteinemias pbc primary protein proteingap syndrome workup
Beta-Blockers in Cirrhosis • Pathophysiology • Indications: Prevention of decompensation, Prevention of first variceal bleeding,
Beta-Blockers in Cirrhosis ... • Pathophysiology ... , Carvedilol #BetaBlockers ... #Cirrhosis #hepatology ... #management #pharmacology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary Cirrhosis ... Pathophysiology ... cholestasis → Cirrhosis ... bile ducts Differential ... diagnosis #workup #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... initiation • Differential ... fluid overload, PCC ... diagnosis #management #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Liver disease: Cirrhosis ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology
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