6 results
diagnosis hematology management monoclonal aflp aplastic apml differentiation gap globulin liver mgus obgyn obstetrics paraproteinemias pregnancy protein proteingap significance syndrome
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Liver #Pregnancy #hepatology ... diagnosis #management #pathophysiology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... No evidence of anemia ... insufficiency, Anemia ... MGUS #Monoclonal #Gammopathy ... #diagnosis #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... • ↓ WBC • ↓ PLT ... Marrow hypoplasia/fatty ... #oncology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
or polyclonal gammopathy ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... initiation • Differential ... fluid overload, PCC ... diagnosis #management #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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