11 results
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... o CML - bcr-able ... o Other bcr-able ... #hematology #Markers
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... lymphoproliferative disorders ... • Neutropenia, anemia ... #Chronic #Lymphocytic ... Leukemia #diagnosis #workup
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... leukemia in adults • Disorder ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... fludarabine) 3) Monoclonal
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... • hemolytic anemia ... sensitize red blood cells ... #hematology #diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Hematologic disorder ... No evidence of anemia ... marrow plasma cells ... insufficiency, Anemia ... #Significance #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... activity • ↓ LAP ... - infiltrates (anemia ... /Cytopenias • AIHA ... #Leukemia #Hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Organomegaly+↑RBC/plt ... Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... myeloma • Plasma cell ... Connective tissue disorders ... Thalassemia, Sickle cell ... anemia • Other
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Marrow Failure • Chronic ... Neutropenia • Platelet Disorders ... Workup: • Complete
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Angioimmunoblastic T-cell ... Hematologic: • AIHA ... • Anemia of inflammation ... with Lupus: • Chronic ... B-cell activation