11 results
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... o CML - bcr-able ... o Other bcr-able ... #hematology #Markers
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... globulin gap (> ... gastric tumors • Hematology ... anemia • Other ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
lymphoproliferative disorders ... • Neutropenia, anemia ... increase in gamma globulins ... Leukemia #diagnosis #workup ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... leukemia in adults • Disorder ... 5) Symptoms of anemia ... fludarabine) 3) Monoclonal ... Leukemia #oncology #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
disorder characterized ... No evidence of anemia ... marrow plasma cells ... insufficiency, Anemia ... #Significance #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
women • 15% of AIHA ... lymphoproliferative disorder ... • Symptoms of anemia ... • hemolytic anemia ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... activity • ↓ LAP ... - infiltrates (anemia ... /Cytopenias • AIHA ... #Leukemia #Hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Organomegaly+↑RBC/plt ... (-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Marrow Failure • Chronic ... Workup: • Complete ... Syndromes #diagnosis #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Angioimmunoblastic T-cell ... : • AIHA 10% • ... • Anemia of inflammation ... with Lupus: • Chronic ... B-cell activation