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diagnosis hematology oncology differential hemolytic autoimmune chronic cll lymphocytic management agglutinin causes cell cold disorders erythematosus gap globulin hemeonc lupus
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... Diagnosis Table ... Cold Agglutinin Disease ... #Diagnosis #Table ... #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic Anemia ... esp if severe disease ... underlying condition • Monoclonal ... Autoimmune #Hemolytic #Anemia ... #management #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... cytopenias (ITP, AIHA ... chemotherapy for low-risk disease ... fludarabine) 3) Monoclonal ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... thrombocytopenia • AIHA ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... count • ↓Hg & PLT ... /Cytopenias • AIHA ... #Hematology #Oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... • hemolytic anemia ... #hemolytic #anemia ... #hematology #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Organomegaly+↑RBC/plt ... Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... Sneddon-Wilkinson disease
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... PT, aPTT(liver disease ... changes), high MCV anemia ... Diagnosis #Causes #Workup ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Causes of Monoclonal ... • Plasma cell leukemia ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Antiribosomal P, APLA, PAC ... Hematologic: • AIHA ... lymphopenia, low PLT ... • Anemia of inflammation ... Hodgkin lymphoma and leukemia
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