7 results
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... hyperviscosity, lymphadenopathy ... #Monoclonal #Gammopathy ... #Significance #hematology ... #diagnosis #oncology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Acute • Myloid (AML ... ALL) - PAS, TdT Lymphadenopathy ... #hematology #Markers ... #Differential #
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... activity • ↓ LAP ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Organomegaly+↑RBC/plt ... Autoantibodies: • WAIHA • CAD ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... younger pts) Differential ... IgM monoclonal gammopathy ... significance (MGUS ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Include: • MGUS ... Connective tissue disorders ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Neutropenia • Platelet Disorders ... compounds, alcohol, lead ... blood count with differential ... #oncology