13 results
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... diagnosis #algorithm #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... Cholangitis (PBC ... Infiltrative diseases - PSC ... - Other biliary ... Diagnosis #Algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... biliary obstruction ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Cirrhosis (PBC) ... intralobular bile ducts causes ... obstruction • ALP ... or higher • Liver ... diagnosis #workup #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Bile Ducts • PSC ... Duct Stone • Biliary ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
to multi-focal biliary ... colorectal and hepato-biliary ... disease management ... Cholangitis #diagnosis #management ... #summary #Hepatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... Imaging: CXR- pulmonary ... fluid overload, PCC ... #diagnosis #management ... #hematology #oncology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... = nonspecific (nausea ... headache, malaise) → Acute ... Cr, ↓Glucose, ↓PLT ... Pregnancy #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
subclinical disease to acute ... reported (eg AIH-PBC ... Anti-LKM & Anti-ALC ... regarding need for treatment ... #Hepatology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Presence of CP or PC ... > 3 mg/dL) or acute ... liver failure ... #Indications #management ... #hepatology