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diagnosis hepatology aflp biliary cholangitis cirrhosis differentiation elevation fatty hepatitis injury lfts liverenzymes obgyn obstetrics oncology pathophysiology pbc phosphatase pregnancy
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... Bone symptoms - Pain ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Vascular Causes ... Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... Labs: • Alkaline ... obstruction • ALP ... or higher • Liver ... bile ducts Differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... Bile Ducts • PSC ... #Causes
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... vomiting, abdominal pain ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Pregnancy #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... initiation • Differential ... fluid overload, PCC ... #diagnosis #management ... #hematology #oncology
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