9 results
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Tests - Differential ... Wilsons, Pregnancy - AFLP ... Ducts - PBC ... , PSC, Alcoholic ... Biliary stricture, PSC
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... Bone symptoms - Pain ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Pregnancy - AFLP ... disease US — Normal ... Bile Ducts • PSC ... Others #LFTs #Hepatology ... #Causes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Vascular Causes ... Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
) - Summary PBC ... intralobular bile ducts causes ... obstruction • ALP ... bile ducts Differential ... diagnosis #workup #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... vomiting, abdominal pain ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Liver #Pregnancy #hepatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
effusions, weight gain ... initiation • Differential ... 500 mg QD until normal ... fluid overload, PCC ... APML #diagnosis #management
Primary Biliary Cirrhosis - Management
A. Initiate therapy 
 - Initiate 1st line therapy with UDCA (13-15
/or prognostic criteria ... line therapy if ALP ... 1.5x ULN and/or abnormal ... survey disease #PBC ... #Treatment #hepatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hemolytic anemia • Pain ... products that define normal ... Immunohistochemical studies (to differentiate ... through Ann Arbor criteria ... #oncology #management