19 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... Intestine - Other causes ... Cholangitis (PBC ... - PSC - Other ... biliary diseases
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Cirrhosis (PBC) ... intralobular bile ducts causes ... obstruction • ALP ... or higher • Liver ... bile ducts Differential
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
(PSC) PSC is a ... to multi-focal biliary ... colorectal and hepato-biliary ... disease management ... #diagnosis #management
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... hepatitis, Acute biliary ... Malignancy, 1° PBC ... , 1° PSC, Cystic
Causes of Fat Malabsorption - Differential Diagnosis
Biliary Duct Obstruction
 • Autoimmune— PBC, PSC
 • Infection— liver
Causes of Fat Malabsorption ... Diagnosis Biliary ... • Autoimmune— PBC ... , PSC • Infection ... — liver fluke, HIV
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Cholestatic disease ... Bile Ducts • PSC ... Duct Stone • Biliary ... Diagnosis #Algorithm #Causes
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
metabolism accumulate → Fat ... = nonspecific (nausea ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... obgyn #diagnosis #management
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... to acute liver ... reported (eg AIH-PBC ... Anti-LKM & Anti-ALC ... regarding need for treatment
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Presence of CP or PC ... transmission prophylaxis at ... infection with severe liver ... mg/dL) or acute liver ... #Indications #management