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diagnosis hepatology algorithm injury obgyn obstetrics acidosis acute aflp aih alkaline alp autoimmune cholangitis cirrhosis classification fat fatty globulin hbv
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Acute biliary ... Malignancy, 1° PBC ... , 1° PSC, Cystic
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential ... Intestine - Other causes ... Cholangitis (PBC ... Infiltrative diseases - PSC ... #Differential #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Algorithm Vascular Causes ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... failure PBC ... • Fatigue PBC
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
- Differential ... Diagnosis Biliary ... • Autoimmune— PBC ... , PSC • Infection ... — liver fluke, HIV
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Bile Ducts • PSC ... • Alcoholic hepatitis ... Duct Stone • Biliary ... Diagnosis #Algorithm #Causes
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... reported (eg AIH-PBC ... (rare) - IgG Elevation ... (eg Viral) Management ... regarding need for treatment
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
HBV, EBV, VZV, hepatitis ... Sarcoidosis) • Liver ... ETOH, autoimmune hepatitis ... , PBC, PSC, Viral ... #ProteinGap #differential
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... Presence of CP or PC ... mg/dL) or acute liver ... failure #HepatitisB ... #Indications #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... , ↑Tbili/Dbili/AP ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Diagnosis: Viral Hepatitis
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