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differential hemophagocytic hepatology hlh lymphohistiocytosis rheumatology algorithm alp aplastic biliary cholangitis cirrhosis classification elevation erythematosus gap globulin hemeonc hodgkins leukemia
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Intestine - Other causes ... - Drugs - Primary ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... intralobular bile ducts causes ... Labs: • Alkaline ... #workup #hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... and petechiae Causes ... • ↓ WBC • ↓ PLT ... #oncology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... assessment+++ Primary ... solid cancers • Autoimmune ... #management #treatment ... #summary #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... Thalassemia, Sickle cell anemia ... #differential #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... + distinctive primary ... #Leukemia #Hematology ... #Oncology #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... disease • Non-autoimmune ... the context of primary ... Antiribosomal P, APLA, PAC ... • Anemia of inflammation
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... Weight loss • Anemia ... Immune hemolytic anemia ... classification #hematology ... #oncology #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Types of HLH • Primary ... Malignancies ▪ Autoimmune ... - Cytopenias (anemia ... #Management #Hematology
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