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oncology management anemia aplastic apml cell cholangitis cirrhosis differential differentiation gap globulin hepatology mds myelodysplasia myelodysplastic pbc plasmacytoma primary protein
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... #workup #hepatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
pericarditis • Hepatic: PBC ... (primary biliary ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... opacities • Diagnosis ... Renal Failure Treatment ... fluid overload, PCC ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- β-lactam antibiotics ... • ↓ WBC • ↓ PLT ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... gastric tumors • Hematology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... isoniazid) • Antibiotics ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... EMD myeloma Diagnostic ... UPEP, Serum IFE, FLC ... Bone marrow Treatment ... #Workup #Hematology
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