12 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Algorithm and Causes ... Increased Serum bilirubin ... Anemia #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
non-ICU vs ICU causes ... Hyperbilirubinemia #direct #bilirubin ... #Differential # ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Ascites - Diagnostic Approach and Differential Diagnosis
The most common causes: cirrhosis, malignancy and heart failure. Approx
The most common causes ... more than one cause ... brown: elevated bilirubin ... Jcortesizaguirr #Ascites #workup ... Diagnosis #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... #differential # ... diagnosis #hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
as jaundice on clinical ... associated with bilirubin ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... >10 mmHg - clinically ... function: INR, bilirubin ... #Hypertension #Differential ... #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Systemic lupus ... nervous system (CNS ... SJIA], systemic lupus ... ↑ AST ↑ ALT ↑ bilirubin ... Diagnosis #Management #Hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... slightly elevated • Bilirubin ... bile ducts Differential ... cholangitis #diagnosis #workup ... #hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... anemia Indirect bilirubin ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... an underlying cause ... Better call hematology ... JAK2 V617F) and MPNs ... #hematology