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diagnosis differential dermatology hemolytic rheumatology antinxp2dm classification dermatomyositis dyspnea extravascular hemolysis intravascular leukemia management mds monoclonal myelodysplasia myelodysplastic nonpalpable palpable
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... Other agents ex. lead ... • Transfusion reactions ... #Hemolytic #Anemia ... classification #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... hemoglobinuria (PNH ... Extravascular #Causes ... differential #diagnosis #hematology ... #anemia
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Cardiovascular Causes ... Heart failure - CAD ... - Water - Pus ... Transverse myelitis • Hematology ... : - Anemia •
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... deficiencies - PNH ... fever • Drug reactions ... Differential #Diagnosis #hematology ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Amyloidosis (CVS+PNS ... Autoantibodies: • WAIHA • CAD ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... -> AML: Blast crises ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... compounds, alcohol, lead ... Syndromes #diagnosis #hematology ... #oncology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Pts have more ... Muscle atrophy may cause ... antibody positive had ... three days #AntiNXP2DM ... #AntiNXP2 #Dermatomyositis
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