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coagulation diagnosis abnormal anticoagulant apixaban cascade dabigatran dic differential disseminated heparin inhibitor intravascular management models pathophysiology pathway platelet prolonged ptt
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... Rivaroxaban, apixaban, edoxaban ... e.g. heparin ... #differential #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
platelet #thrombin #clot ... #PT #PTT #diagnosis ... #models #hematology ... #Rivaroxaban #Edoxaban ... #heparin #pathway
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... significant fibrin clot ... Treat primary cause ... treatment #management #hematology
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