6 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... intravascular coagulation (DIC ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... intravascularcoagulation (DIC ... #Prolonged #Causes ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... INR < 2.3 - APTT ... Coagulation #diagnosis #causes ... treatment #management #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... deficiencies - PNH ... Cholesterol emboli • Septic ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Bleeding and Bruising ... Acquired: • Heparin ... the PT remains prolonged ... discern these causes ... #Diagnosis #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... PLT: Petechiae, bruising ... Fibrinolysis & DIC ... #Leukemia #Hematology ... #Oncology #Diagnosis