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diagnosis differential management generalized pruritus rheumatology allergy dress eczematous erythematosus hemeonc hemophagocytic hlh lupus lymphohistiocytosis macrophage mas naildisorders polycythemia primary
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Classified among the secondary ... (CNS) dysfunction ... Petechial or purpuric rash ... #Management #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Primary Causes ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #dermatology #Differential ... #causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... • Nephrotic syndrome ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm ... #causes
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
into a 4-pass system ... pass = Dangerous secondary ... • Mast cell activation ... syndrome • Mastocytosis ... Differential #Diagnosis #hematology
Eczematous Skin Rash - Differential Diagnosis Algorithm Eczematous - Pruritic/Scaly/Erythematous lesions. Usually poorly demarcated • Atopic Dermatitis
Eczematous Skin Rash ... Secondary to venous ... pigmentation, edema ... Eczematous #SkinRash #dermatology ... #causes
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Malignancy (e.g. hematologic ... lower extremity edema ... • May involve PNS ... Chronic B-cell activation
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Eosinophilia and Systemic ... extensive skin rash ... • Facial Edema ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Myelodisplastic syndrome ... #Pruritus #secondary ... #systemic #generalized ... #dermatology #Differential ... #causes
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... frequently affected systems ... Better call hematology ... JAK2 V617F) and MPNs ... #workup #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... activation of the ... immune system ... STX11, STXBP2 • Secondary ... Diagnosis #Management #Hematology
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