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Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
of Sickle Cell Crises ... Clinical Manifestations ... Diagnosis #Management #Hematology ... #SickleCell #Complications
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
other orthopedic complications ... • XR, MRI to ... Osteomyelitis / Septic Arthritis ... #Joint #Pain #SickleCell ... #hematology
Gout (Gouty Arthritis) - MSK Radiology
Imaging Findings:
 • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Gout (Gouty Arthritis ... ) - MSK Radiology ... • PVNS/Giant Cell ... #mri #clinical ... #msk #rheumatology
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... ancestry, LGE on MRI ... Thromboembolic complications ... support for patients clinically ... diagnosis #management #cardiology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... • May involve PNS ... Thrombosis highest risk ... Erythematosus #Diagnosis #Rheumatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... nonerosive inflammatory arthritis ... Rule out other causes ... - MRI: inflammation ... SAPHO #Syndrome #Rheumatology
UCSF COVID-19 Adult Clinical Evaluation Guide - Updated April 10 2020

Clinical Presentation
• Fever: hospitalized pts but
: hospitalized pts ... dyspnea 20-50% • URI ... Cardiac: multiple case ... 7-28% -> Incr risk ... complications,
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... and ophthalmic complications ... Diagnosis = clinical ... identifies 85 to 95% of cases ... them, but urgent rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis ... Sjogrens #Syndrome #Rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
increased infection risk ... to 8 years Clinical ... noninfectious complications ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology