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diagnosis differential management brain endocarditis rheumatology cardiomyopathy clinical crypto emergencies hemeonc infectiousdiseases lesions leukemia meningitis mri myopathy myositis neurology oncologic
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
CNS Ring-Enhancing ... + toxo IgG • CNS ... 30% present w/ CNS ... @AnnKumfer #CNS ... #radiology #neurology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... effusion, INC risk ... Malignancy Risk
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
mg/dL or > 25 % rise ... Treat underlying cause ... interventional radiology ... ) - Symptoms: CNS ... ) - Symptoms: CNS
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... leukostasis syndrome: CNS ... Transformation: • Complication ... #Leukemia #Hematology ... #Oncology #Diagnosis
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Risk Factors and ... • Minority of Pts ... Thromboembolic complications ... diagnosis #management #cardiology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
regurgitation • Autoimmune ... Aspergillus • Cryptococcus ... Septic Emboli Cause ... destructive lesion • Complications ... diagnosis #management #cardiology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
regurgitation • Autoimmune ... Aspergillus • Cryptococcus ... Septic emboli cause ... destructive lesion • Complications ... Differential #Diagnosis #cardiology
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
low glucose) CNS ... Nausea & vomiting ... performed, relative risk ... have a higher risk ... Brain #clinical #radiology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... nucleotidase 1A (Anti cN ... aspiration > 50% of pts ... statins - probably caused ... Myositis #Myopathy #rheumatology
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