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diagnosis differential management polycythemia autoimmune common cvid erythrocytosis essential et fever hypogammaglobulinemia immunecompromised immunocompromised immunodeficiency immunology leukemia myopathy myositis oncology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Differential Diagnosis Algorithm ... Splenomegaly, Increased PMNs ... Sleep Apnea • Chronic ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... with a relatively chronic ... -> AML: Blast crises ... Transformation: • Complication ... #Leukemia #Hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... circulation = risk ... Better call hematology ... normal/high - Chronic ... #workup #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
increased infection risk ... noninfectious complications ... Autoimmunity • Chronic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... jirovecii • CNS ... Bronchitis • Chronic ... #Causes #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... effusion, INC risk ... Nephrogenic DI Hematologic ... lubricants • Pharmacologic ... Sjogrens #Syndrome #Rheumatology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
(ET) ET is a chronic ... , symptoms and complications ... • Treatment algorithms ... Thrombocythemia #ET #hematology ... diagnosis #management #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... aspiration > 50% of pts ... statins - probably caused ... muscular atrophy • Chronic ... Myositis #Myopathy #rheumatology
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