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diagnosis neurology rheumatology bee management syndromes algorithm encephalopathy erythematosus floppy hypotonic infant inflammatory lesions lupus monoclonal myopathy myositis newborn noninflammatory
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
affecting the brain ... nervous system (CNS ... an underlying autoimmune ... Inflammatory causes ... #inflammatory #differential
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
CNS Ring-Enhancing ... + toxo IgG • CNS ... 30% present w/ CNS ... #differential # ... diagnosis #causes
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... +PNS+GI+Endocrine ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory Causes ... affecting the Brain ... nervous system (CNS ... an underlying autoimmune ... noninflammatory #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... effusion, INC risk
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
parietal lobes of the brain ... /Sepsis/Shock, Autoimmune ... Risk factors 3. ... Reversible course Differential ... the underlying cause
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... disease • Non-autoimmune ... • May involve PNS ... and CNS • Headache ... Thrombosis highest risk
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm Central Nervous System - Decreased LOC, Axial
Causes of Hypotonic ... Normal Reflexes - Brain ... Hemorrhage • CNS ... Other Congenital Syndromes ... #Peds #Pediatrics
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... nucleotidase 1A (Anti cN ... aspiration > 50% of pts ... statins - probably caused ... #differential #
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