19 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #CNS #neurology ... #rheumatology #
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
CNS Ring-Enhancing ... + toxo IgG • CNS ... 30% present w/ CNS ... #differential # ... diagnosis #causes
Algorithm for evaluating multiple ring-enhancing lesions in immunocompetent (HIV negative)

#ringenhancing #lesions #cns #brain #diagnosis #differential #algorithm
ringenhancing #lesions #cns ... #brain #diagnosis ... #differential # ... algorithm #causes ... #radiology #neurology
Alice in Wonderland Syndrome
What? Metamorphophsia - Distortions of the visual perceptions with changes in size (micro
CNS: parietal ... (Many causes!) ... encephalitis) • Brain ... • Psychiatric disorders ... diagnosis #neurology #differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... l MD SOAP) - Risks ... test, ANA (e.g., SLE ... #Differential # ... #Workup #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Splenomegaly - CTD (SLE ... deficiencies - PNH ... Associated - SLE ... #Diagnosis #hematology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
affecting the brain ... nervous system (CNS ... Inflammatory causes ... optica spectrum disorder ... #inflammatory #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Malignancy (e.g. hematologic ... • May involve PNS ... and CNS • Headache ... Thrombosis highest risk
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... leukostasis syndrome: CNS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... • Infectious causes ... ruled out • Brain ... MRI: Check for brain ... management #neurology #differential