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diagnosis differential algorithm hemolysis agglutinin cold disease disorders extravascular hemeonc hemophagocytic hlh intravascular key lesions leukemia lymphohistiocytosis management nomenclature nonpalpable
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Urobilinogen • + urinary ... #Hemolytic #Anemia ... #Differential #Causes ... #Workup #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... Bleed • Hemolysis ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... usually IgM) (e.g. primary ... differential #diagnosis #hematology ... #anemia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Post-splenectomy Primary ... #hematology #secondary
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... deficienies Labs: - Basic ... changes), high MCV anemia ... unclear, or if a primary ... #Workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Secondary Cold ... lymphoproliferative disorder Secondary ... anemia • Cold ... #anemia #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Better call hematology ... up EPO levels Primary ... JAK2 V617F) and MPNs ... #hematology
Primary Dermatological Lesions Primary lesions are physical changes in the skin considered to be caused directly by
considered to be caused ... associated with secondary ... #Diagnosis #Dermatology ... #Nomenclature #Atlas ... #Key #Basics
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... + distinctive primary ... bone marrow and secondary ... #Leukemia #Hematology
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