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diagnosis rheumatology differential management syndrome systemic algorithm antimda5 antimda5dm antinxp2 antinxp2dm autoimmune dyspnea erythematosus lupus myopathy myositis naildisorders oncology secondary
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Water - Pus ... Barre - ALS - Transverse ... myelitis • Hematology ... : - Anemia • ... #pulmonary
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Scleroderma • Dermatomyositis ... Iron deficiency anemia ... Muehrcke's Lines - Transverse ... Systemic #Secondary #dermatology ... Diagnosis #Algorithm #causes
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... • Arthralgia/arthritis ... dermatology #diagnosis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... Causes: - Idiopathic ... , breast CA - Hematologic ... multiforme - Dermatomyositis ... Syndrome #diagnosis #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Still disease, dermatomyositis ... Malignancy (e.g. hematologic ... • May involve PNS ... neuropathy • Transverse ... lymphopenia, low PLT • Anemia
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... May develop in pts ... tract, and often causes ... arthritis. ... Differential #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... peripheral neuropathy, transverse ... , INC risk PE, Pulmonary ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
subcutaneous edema Pts ... chest (in a V-sign ... shoulders (in a shawl sign ... Muscle atrophy may cause ... #dermatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
papules and Gottron sign ... ) • Shawl sign ... aspiration > 50% of pts ... • Nonerosive arthritis ... statins - probably caused
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