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diagnosis differential oncology rheumatology leukemia management algorithm aplastic arterial cellulitis chronic disorders dyspnea embolism eosinophil erythematosus extravascular gap globulin hemolysis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... (common causes ... are asthma, allergy ... symptoms (eg, skin ... Differential #diagnosis #hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... Rhinitis - Allergic ... Primary: - CML ... Hypereosinophilic Syndrome ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... - infiltrates (anemia ... • Tumor lysis syndrome ... -> Invade Skin: ... #Leukemia #Hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Water - Pus ... Hepatopulmonary syndrome ... Barre - ALS - Transverse ... myelitis • Hematology ... : - Anemia •
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... hemoglobinuria (PNH ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology ... #anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Neutropenia, anemia ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... - Hemolytic anemia ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Alpha & Mu) Skin ... (-) hemolytic anemia ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Out Secondary Causes ... Workup: • Complete ... #diagnosis #hematology
Causes of Pseudocellulitis - Differential Diagnosis Framework for Cellulitis Mimics Cellulitis: Deep skin and subcutaneous fat infection Pseudo
Cellulitis: Deep skin ... antibiotics and avoid allergic ... Sarcoidosis • Eosinophilic ... • Compartment syndrome ... #dermatology #skin
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