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diagnosis differential management rheumatology cns anemia aplastic cerebritis erythematosus lesions leukemia lupus monoclonal paraproteinemias radiology ringenhancing sjogrens sle systemic treatment
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
Diagnosis- Compatible syndrome ... , may also see skin ... RingEnhancing #Lesions #Brain ... differential #diagnosis #causes ... #radiology #neurology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... Amyloidosis (CVS+PNS ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #neurology #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... - Hepatitis, eosinophilic ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, neurologic, and ... cognitive impairment, neurologic ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... tract, and often causes
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... Hypocomplementemia • Can cause ... peripheral neuropathy, transverse ... amyloidosis, PAH Skin ... Nephrogenic DI Hematologic
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