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diagnosis differential management algorithm chronic cll hodgkins lymphocytic agglutinin aplastic causes classification cold comparison diffuse disease gap globulin hemeonc hemolytic
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Infectious • EBV ... Non-Hodgkin's Lymphoma ... Reed-Sternberg Cells ... Algorithm #Causes #Hematology ... #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- Blood & BM • ... • Cytopenia -> BM ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Skin: - CLL cells ... or basket cells ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... involved) • No leukemic ... • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... Parvovirus B19 - EBV ... Epstein-Barr virus (EBV ... ) • Leukemia ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Weight loss • Anemia ... Immune hemolytic anemia ... classification #hematology ... #oncology #management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
lymphocytes, smudge cells ... 5) Symptoms of anemia ... to large cell lymphoma ... marrow failure with anemia ... #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... - Mycoplasma, EBV ... sensitize red blood cells ... #hematology #diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia ... differential #diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
HBV, HCV, HEV, EBV ... , PSC, IgG4, HLH ... cell lung CA, lymphoma ... intestines, white blood cells ... diagnosis #algorithm #hepatology
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