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diagnosis hematology agglutinin anemia associations autoantibodies autoimmune classification cold disease diseases gap hemolytic myopathy myositis protein proteingap vasculitides vasculitis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... diseases #diagnosis #table ... #rheumatology # ... antibodies
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
[PCH] 3. ... - Mycoplasma, EBV ... younger pts) Differential ... Disorders Such As ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... Gap #ProteinGap #differential ... #diagnosis #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... glomerulonephritis) • Anti-GBM ... to exclude are infections ... C-ANCA) pattern: antibodies ... #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Tenderness → Consider infectious ... RP-ILD), dermato-rheumatologic ... • ANA < 20 % IBM ... #differential #
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