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differential algorithm anemia hepatology liver acute agglutinin antibodies aplastic associations autoantibodies autoimmune causes cold disease diseases gap globulin hemolytic hepatitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... C, A, E, B, D, EBV ... Malignancy, 1° PBC ... , 1° PSC, Cystic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... HBV, HCV, HEV, EBV ... #differential #diagnosis ... #algorithm #hepatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Dermatomyositis Anti-LKM (liver ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... Associations #diseases #diagnosis ... #table #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... Presentation: • Fever ... recurrent infections/fevers ... Anemia #oncology #hematology ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... - Mycoplasma, EBV ... Hemoglobinuria (PCH ... Symptoms: High fevers ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Overlap Syndrome: Fever ... • ANA < 20 % IBM ... ANTI-SYNTHETASE SYNDROME: • Fever ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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