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differential hematology agglutinin anemia antibodies associations autoantibodies autoimmune cdi cdiff clostridioides clostridium cns cold difficile disease diseases encephalitis gap gastroenterology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Drug-induced SLE Anti-Jo-1 ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... Associations #diseases #diagnosis ... #table #rheumatology
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
: HSV 1): • Herpes ... simplex virus 1 ... virus • CMV • EBV ... • Headache • Fever ... meningeal signs (fever
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Antibodies: 1. ... Donath-Landsteiner Antibodies[PCH ... - Mycoplasma, EBV ... Hemoglobinuria (PCH ... Symptoms: High fevers
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Acute Diarrhea (>3 BM ... mucus, Abd pain, Fever ... Epidemiology: • #1 ... non-toxigenic • Stool PCR ... 10 mg/kg IV x 1
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... lung cancers, HCC ... SPEP can: 1. ... #differential #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Ab • Anti-Jo-1 ... Overlap Syndrome: Fever ... • ANA < 20 % IBM ... ANTI-SYNTHETASE SYNDROME: • Fever ... Other Diseases: • PBC
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