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diagnosis hematology classification hodgkins lymphoma management vasculitis adultonset agglutinin aids anemia autoimmune cns cold comparison gap globulin hemolytic hiv infections
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad: Fever ... fraction < 20% Differential ... Coxsackie, CMV, EBV ... management #treatment #rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
., HIV), EBV infection ... - Pel-Ebstein fever ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH ... Symptoms: High fevers ... hemolytic #anemia #hematology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
• Symptoms: Fever ... • Symptoms: Fever ... Demyelinating disease ... effect/Edema • EBV ... opportunistic #InfectiousDiseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... glomerulonephritis) • Anti-GBM ... Coronary arteries - Fever ... Vasculitis: • Fevers ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... and branches • Fever ... Coronary arteries • Fever ... pain and GN Anti-GBM ... #Diagnosis #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... cells - Blood & BM ... • Cytopenia -> BM ... Headaches, bone pain, fever ... #Oncology #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... • Dyspnea • Fever ... Immunohistochemical studies (to differentiate ... number of sites of disease ... #oncology #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Heavy chain disease ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... disease: Cirrhosis ... Gap #ProteinGap #differential
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Overlap Syndrome: Fever ... • ANA < 20 % IBM ... ANTI-SYNTHETASE SYNDROME: • Fever ... #differential #
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