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diagnosis management hematology classification hodgkins infections lymphoma oncology vasculitis 1 adultonset agglutinin aids anemia autoimmune cdi cdiff clostridioides clostridium cns
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... fraction < 20% Differential ... Coxsackie, CMV, EBV ... diagnosis #management #treatment ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... #summary #rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
., HIV), EBV infection ... - Pel-Ebstein fever ... involvement Differential ... oncology #diagnosis #differential ... #hematology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Antimicrobial treatment ... • Symptoms: Fever ... • Symptoms: Fever ... Demyelinating disease ... effect/Edema • EBV
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH ... Symptoms: High fevers ... hemolytic #anemia #hematology
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Acute Diarrhea (>3 BM ... mucus, Abd pain, Fever ... non-toxigenic • Stool PCR ... IDSA 2021 CDI Treatment ... #infectiousdiseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... glomerulonephritis) • Anti-GBM ... Coronary arteries - Fever ... Vasculitis: • Fevers ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... and branches • Fever ... Coronary arteries • Fever ... pain and GN Anti-GBM ... #Diagnosis #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... • Dyspnea • Fever ... Immunohistochemical studies (to differentiate ... number of sites of disease ... Hodgkin Lymphoma Treatment
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Heavy chain disease ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... disease: Cirrhosis ... Gap #ProteinGap #differential
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