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diagnosis differentiation hematology igg4 oncology rheumatology syndrome
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... ATRA treatment Pathophysiology ... • Steroids: IV ... severe APLS, organ dysfuxtion ... #diagnosis #management
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... PATHOPHYSIOLOGY ... progressive organ dysfunction ... Cholangitis - mimics PSC ... complement • Classification
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