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differential ana antibodies antinuclear apml differentiation disease hemophagocytic hlh infections infectiousdiseases lymphohistiocytosis mycoses myelitis neurology oncology patterns polychondritis relapsing tafro
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
syndrome (Clinical ... Arthritis, AS Treatment ... #Syndrome #diagnosis ... #management #signs ... #symptoms #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Syndrome Diagnosis ... salivary ducts Clinical ... #Syndrome #Rheumatology ... #Diagnosis #Management
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... likely it will be clinically ... Primary Biliary Cirrhosis ... , Interstitial Pulmonary ... ANA #patterns #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Pathophysiology ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... : HLH signs and ... #management #treatment ... #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... or without back pain ... • Bilateral signs ... and/or symptoms ... #management #neurology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Sudden onset of pain ... Sarcoidosis • Behcet ... ○ Syphilis ○ Fungal ... Polychondritis #rheumatology ... #diagnosis #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... , chest pain • ... , neutropenia, cirrhosis ... Aspergillosis Pathophysiology ... #Diagnosis #Management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
IGG4 - Hepatic cirrhosis ... cell lymphoma Pathophysiology ... and the systemic symptoms ... Hypoalbuminemia Treatment ... #management #rheumatology
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