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differential hematology causes management syndrome algorithm anemia oncology aplastic classification eosinophil eosinophils erythematosus extravascular hemolysis hemolytic hes hypereosinophilia intravascular leukocytosis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm INDICATIONS ... asthma, allergy, drug ... #Differential #diagnosis ... #hematology #eosinophilia
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential Diagnosis ... - Parasites Drugs ... - DRESS - AIN ... #Causes #hematology
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
Syndrome (HES) - Diagnosis ... Secondary Causes ... : - Allergic disorders ... - Drug hypersensitivity ... #diagnosis #hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
- Differential Diagnosis ... • Eosinophilia ... Malignancy, Autimmune, Drugs ... #Differential #Diagnosis ... #causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... lymphoproliferative disorders ... infection) - Drugs ... #hematology #anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Arthritis: • Joint pain ... extremities Drug ... activation and/or medications ... #Rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Vasculitis - Collagen disorders ... lesions • Severe pain ... Immunosuppressed • New medication ... Autoimmune Vasculitis (lupus ... #dermatology #physicalexam
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
chronic inflammatory disorder ... Autoinflammatory disorder ... Rule out other causes ... SAPHO #Syndrome #Rheumatology ... #Dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... #rheumatology #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Cytotoxic drugs ... - Antithyroid medications ... - Hepatitis, eosinophilic ... Anemia #oncology #hematology ... #diagnosis #management
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