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Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Small Vessel: Petechiae ... , Palpable purpura ... Vasculitis: • Behcet ... Disease • Cogan syndrome ... #dermatology #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... , Palpable purpura ... • Palpable purpura ... • Goodpasture syndrome ... #diagnosis #rheumatology
Vancomycin induced Leukocytoclastic Vasculitis (LCV) of the Hand
70 M vertebral osteomyelitis on vancomycin and cefepime for
Presents with diffuse palpable ... rash. ... Diagnosis? ... atrial myxoma, Behcet ... #photo
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... sign of cutaneous leukocytoclastic ... , mucositis • Rash ... vasculitis • Behcet ... #Rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
purpura, Pathergy ... syndrome (Clinical ... #Syndrome #diagnosis ... #management #signs ... #symptoms #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
mucositis - Rash ... VASCULITIS: • Behçet ... scleritis • Palpable ... sign of cutaneous leukocytoclastic ... #rheumatology #
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Clinical Presentation ... mucosal bleeding (Petechial ... or purpuric rash ... #Diagnosis #Management ... #Hematology #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... Manifestations of DIC: • Petechiae ... Palpable variants ... #Coagulation #diagnosis ... causes #treatment #management