12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... IgA nephropathy, Henoch-SchonIein ... Purpura Anti-GBM ... #diagnosis #algorithm ... #rheumatology
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
- Differential ... • ↓C4: Lupus, Cryoglobulinemia ... IgA Nephropathy, Henoch ... Schonlein Purpura ... diagnosis #nephrology #causes
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... reticularis Differential ... • Henoch-Schönlein ... cryoglobulinemia ... #diagnosis #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... infection - RMSF - Henoch ... Schonlein Purpura ... Rash: - Purpura
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
Rashes- THE ALGORITHMIC ... endocarditis, RMSF, and Henoch-Schönlein ... rash, the diagnosis ... #Purpuric #Rash ... #Differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... OF PALPABLE PURPURA ... vasculitis/HSP • Cryoglobulinemia ... vasculitis - GPA ... #rheumatology #
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Crohn's disease Palpable ... vasculitis • Henoch ... Schönlein purpura ... Sarcoidosis • GPA ... #diagnosis #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Skin ulcers - Glomerulonephritis ... Clinical triad of Palpable ... IgA vasculitis (Henoch-Schönlein ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often present • Henoch ... Schonlein Purpura ... tract, and often causes ... mucositis - Rash ... #diagnosis #rheumatology
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Diagnosis Algorithm ... Scleroderma • Henoch-Schonlein ... Purpura • Polymyalgia ... polyangiitis (GPA ... #Orthopedics #Causes