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diagnosis differential hematology management pulmonary treatment bronchiectasis classification common cvid disease gap globulin hodgkins hypogammaglobulinemia igg4 immunodeficiency immunology lymphoma myopathy
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... biliary, renal, lung ... concentration PET-CT ... management #phenotypes #workup ... #treatment #rheumatology
Bronchiectasis - Permanent dilation of an airway WHAT CAN YOU SEE ON CT? 1) Lack of tapering of
CAN YOU SEE ON CT ... involving both lungs ... WHAT ARE COMMON CAUSES ... Obstruction 6) Rheumatologic ... /Autoimmune diseae
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung ... lymphocytic interstitial lung ... Chest CT: • Ground-glass ... : Pneumonia • Autoimmune ... DDX - Other causes
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
OnePager Summary Autoimmune ... mononeuritis multiplex WORKUP ... Other tests: • CT ... Goodpasture's cause ... sparing of the lung
Subglottic stenoses (SGS) during systemic diseases Subglottic stenosis (SGS) = congenital (children) or acquired (adult) characterized by
cartilage Diagnostic Work-up ... Cervical and chest CT ... Acquired causes ... Laryngotracheal cancer • Autoimmune ... #rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... , this list is long ... about secondary causes ... As with many disease ... #workup #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... Hodgkin Lymphoma Workup ... Mediastinal mass) • CT ... number of sites of disease ... physical exam, CT
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... , pancreas, stomach ... , pancreas, stomach ... statins - probably caused ... Myositis #Myopathy #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Heavy chain disease ... Sarcoidosis) • Liver disease ... Cirrhosis, ETOH, autoimmune ... ovarian tumors, lung
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