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differential rheumatology disease treatment abscess autoimmune bone classification common cvid gap gca giantcell globulin hodgkins hypogammaglobulinemia igg4 immunodeficiency immunology joint
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... biliary, renal, lung ... concentration PET-CT ... increased IgG4+ cells ... #diagnosis #management
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess - Diagnosis ... • Most common cause ... ) • CXR upright ... seen • Chest CT ... of PCN allergy
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Pain in Sickle Cell ... Generally affects long ... Osteomyelitis / Septic Arthritis ... #differential #diagnosis ... #causes #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... (GCA) Giant cell ... in literature (NEJM ... (Cornelia NEJM ... #Management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... Chest CT: • Ground-glass ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis ... MALT Lymphoma • Lung ... #Diagnosis #Management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Mediastinal mass) • CT ... number of sites of disease ... physical exam, CT ... classification #hematology ... #oncology #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
myeloma • Plasma cell ... (RA, Temporal arteritis ... ovarian tumors, lung ... #differential #diagnosis ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
, pancreas, stomach ... , pancreas, stomach ... • Nonerosive arthritis ... statins - probably caused ... : • PBC, autoimmune
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