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diagnosis differential hematology management dermatomyositis vasculitis algorithm alopecia antimda5 antimda5dm antinxp2 antinxp2dm behcet classification cll hair hairloss hemophagocytic hlh leukemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... • Infections: Chronic ... trauma, Acute pancreatitis ... Diagnosis #Algorithm #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... severity of the disease ... #dermatology #diagnosis
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
present, symptoms, signs ... Splenomegaly Treatment ... • Treatment is ... von Willebrand disease ... #hematology
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Capitis - Skin Disease ... Discoid lupus erythematosus ... Examination: • Signs ... weight loss • Chronic ... Differential #Diagnosis #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Physical Exam/Signs ... cells can indicate disease ... microglobulin Treatment ... workup #oncology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... ischemia - Skin: erythematous ... systemic lupus erythematosus ... purpura: strong sign ... differential #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Syndrome Systemic disease ... Arthritis, AS Treatment ... Recurrent and chronic ... diagnosis #management #signs ... #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... Diagnosis: HLH signs ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
atherosclerotic disease ... purpura: Strong sign ... ischemia • Skin: Erythematous ... Eosinophilia, asthma, chronic ... Differential #Diagnosis #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... shoulders (in a shawl sign ... had more severe disease ... positive patients Treatment ... #dermatology
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