Paraneoplastic Syndrome treatment pulmonary clinical diagnosis infectiousdiseases neurology rheumatology workup clarksons oncology monoclonal infections leak

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Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
(+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia

of Clinical Significance ... Neurologic-Centered ... Systemic capillary leak ... syndrome (Clarkson's ... #hematology #oncology

Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex

Monoclonal gammopathy ... filling +++ (risk of pulmonary ... of infections) ... #syndrome #diagnosis ... #rheumatology

Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
• Lymphocytes accumulate in large numbers

Orange or Hep C Clinical ... weeks without infection ... • MPGN: Paraneoplastic ... microglobulin Treatment ... #workup #oncology

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